Pharmacological effects of Cefepime

Cefepime as the new fourth-generation cephalosporin injection. The product of methicillin-sensitive Staphylococcus aureus, coagulase-negative staphylococci, pneumococci, hemolytic streptococcus, etc. have good antibacterial activity, but methicillin-resistant Staphylococcus aureus, Enterococcus often resistant. The goods on most Enterobacteriaceae role and cefotaxime similar or slightly better, but the Fraunhofer citric acid bacilli, Enterobacter aerogenes, Enterobacter cloacae, Serratia other effect than cefotaxime and ceftazidime. Haemophilus influenzae, Neisseria gonorrhoeae, Mola Ka he monocytogenes (enzyme production and non-producing strains) of the highly sensitive goods.
The product of Pseudomonas aeruginosa is also good, but the effect slightly worse than ceftazidime and imipenem; Acinetobacter, Scott Intuit product is only moderately sensitive to the bacteria. Mechanism of action similar to other β-lactam. Compared with the third-generation cephalosporins, the product of Staphylococcus and Enterobacter (in particular gas and Enterobacter cloacae) stronger role. Cefepime against a variety of plasmid-mediated and chromosome-mediated β-lactamase stability, including chromosome-mediated type I enzyme; This product rarely induce bacterial β-lactamase.


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3-Pyrrolidinol basic information

Chinese: 4 - hydroxy pyrrolidine
Name :3-HYDROXYPYRROLIDINE
3-HYDROXYPYRROLINE
3-PYRROLIDINOL
DL-3-HYDROXYPYRROLIDINE
DL-3-PYRROLIDINOL
Pyrrolidin-3-ol
3-pyrrolidinol (DL)
3-PYRROLIDINOL FREE BASE
Pyrrolidine-3-ol
CAS :40499-83-0
Chinese Name: 3 - pyrrolidinols 3 - hydroxy pyrrolidine pyrrolidinols
EINECS No. :254 -944-5
Molecular formula: C4H9NO
MDL Number: MFCD00005256
Weight: 87.12
MOL File :40499-83-0. Mol
Physical and chemical properties:
Boiling point :108-110 ° C8 mm Hg (lit.)
Density: 1.076 g / mL at 20 ° C (lit.)
Refractive index: n20 / D 1.49 (lit.)
Flash point:> 230 ° F


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3-Aminophenylboronsäure Monohydrat grundlegende Informationen

CAS-Nummer: 206658-89-1

Chemischer Name: 3-Aminophenylboronsäure Monohydrat

Englisch Synonyme: M-APBA; TIMTEC-BB SBB004197; M-Aminophenylboronsäure; 3-Boronoaniline Monohydrat; 3-Aminophenylboronsäure 98 +%, 3-Aminophenylboronsäure Hydrat; 3-Aminobenzeneboronic-Hydrat; 3-Aminophenylboronsäure MONOHYDRATE; B- (3-Amino-phenyl) Boron-Hydrat; 3-Aminobenzeneboronic Monohydrat

Chinesischer Name: 3 - Aminoboronsäure (Monohydrat)

Chinese Synonyme: 4 - Aminophenylboronsäure Monohydrat; M-Aminophenylboronsäure Monohydrat; 3 - Aminoboronsäure Monohydrat; 3 - Aminoboronsäure (Monohydrat), 3 - Aminoboronsäure - Hydrat; 3 - Aminoboronsäure Monohydrat; 3 - Aminophenylboronsäure Monohydrat; 3 - Aminoboronsäure Monohydrat, 97%, 3 - Aminoboronsäure (anhydrid mit unterschiedlichen Mengen); 3 - Aminoboronsäure ein hydrat (enthält unterschiedliche Mengen an Anhydrid)

CBNumber: CB5853311

Formel: C6H10BNO3

Molekulargewicht: 154.96

MOL-Datei: 206658-89-1.mol

3 - Aminoboronsäure (Monohydrat) chemische Eigenschaften

Schmelzpunkt: 94 ° C

Lagerung: 2-8 ° C

Sensitive: hygroskopisch

BRN: 2936342

CAS-Datenbanken: 206658-89-1 (CAS DataBase Reference)

Informationen zur Sicherheit

Kennzeichnung gefährlicher: Xi, Xn

Sätze: 36/37/38-20/21/22

Sicherheits-Sätze: 26-36-37/39

WGK Deutschland: 3

F: 3-10

Hazard Note: Reizend / hygroskopisch

HazardClass: IRRITANT, HYGROSKOPISCHE

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Deuterium oxide effect

Major role:
Heavy water (Deuterium oxide) is mainly used as nuclear reactor moderator and coolant, the amount of up to hundreds of tons. Heavy water is generated by the decomposition of deuterium thermonuclear fuel. Heavy water can be done tracer substances.
Features:
Heavy water and ordinary water in appearance similar, but slightly larger than the density, of 1.1079 g / cc, the freezing point is slightly higher, as 3.82 ℃, boiling point of 101.42 ℃. Participation rates of chemical reactions slower than ordinary water, heavy water a molecule is composed of two heavy hydrogen atoms and one oxygen atom of the formula D2O, relative molecular mass is 20. Heavy water is mainly used as a moderator in a nuclear reactor, which can reduce the rate of neutrons, fission process to conform to the needs. Heavy water is to study the chemical and physical changes in the materials used. Thick and heavy pure animal and plant life can not be maintained, it lethal concentration of 60% to 80%.
Heavy water and ordinary water, is also the liquid hydrogen and oxygen compounds, however, heavy water molecules and the hydrogen atoms of water molecules general different. We know that there are three kinds of hydrogen isotopes. One is protium, it only contains one proton. And a compound which can generate normal oxygen atom of the water molecule. Another is heavy hydrogen - deuterium. It contains a proton and a neutron. Compound and an oxygen atom which can be generated after the heavy molecules. There is also a tritium - deuterium. It contains two neutrons and one proton.
Heavy water and ordinary water similar appearance, is a colorless, odorless liquid. Density than ordinary water, high melting point, high boiling point than ordinary water. As heavy molecular weight, slow motion, so the ice and snow in the mountains, especially in the heavy water content in the Antarctic ice is minimal, water (hydrogen peroxide) the density of the smallest and lightest of the water on Earth. Distributed in nature, less heavy water in ordinary water, heavy water containing approximately 0.015%. Because content, preparation is difficult, so it's price is higher (about 16 yuan / ml).
Although technically advanced heavy water is a precious resource, but it is harmful to human. Are heavy water undrinkable, microorganisms, fish in a pure heavy water or heavy water containing large (over 80%) in water, as long as a few hours will die. On the contrary, especially small light water containing heavy water, snow water, was able to stimulate biological growth


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