Cefepime as the new fourth-generation cephalosporin injection. The product of methicillin-sensitive Staphylococcus aureus, coagulase-negative staphylococci, pneumococci, hemolytic streptococcus, etc. have good antibacterial activity, but methicillin-resistant Staphylococcus aureus, Enterococcus often resistant. The goods on most Enterobacteriaceae role and cefotaxime similar or slightly better, but the Fraunhofer citric acid bacilli, Enterobacter aerogenes, Enterobacter cloacae, Serratia other effect than cefotaxime and ceftazidime. Haemophilus influenzae, Neisseria gonorrhoeae, Mola Ka he monocytogenes (enzyme production and non-producing strains) of the highly sensitive goods.
The product of Pseudomonas aeruginosa is also good, but the effect slightly worse than ceftazidime and imipenem; Acinetobacter, Scott Intuit product is only moderately sensitive to the bacteria. Mechanism of action similar to other β-lactam. Compared with the third-generation cephalosporins, the product of Staphylococcus and Enterobacter (in particular gas and Enterobacter cloacae) stronger role. Cefepime against a variety of plasmid-mediated and chromosome-mediated β-lactamase stability, including chromosome-mediated type I enzyme; This product rarely induce bacterial β-lactamase.
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From:Acridine Raw Material
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